Show HN: Allelix – Annotate your DNA against 7 public databases offline

Category: cli-tool

Tags: dna-analysis, bioinformatics, cli-tool, genomics, python

Score: 7.5/10 (Innovation: 7, Technical: 8, Documentation: 8, Utility: 7)

Allelix is an offline command-line toolkit that analyzes raw DNA genotype files from consumer testing services against multiple public databases like ClinVar and gnomAD. Its innovative combination of format-agnostic ingestion, database-agnostic annotation, and comprehensive offline-first design fills a real need for privacy-conscious genetic analysis, with sophisticated handling of build asymmetries and commercial licensing.

Target audience: bioinformaticians, genetic researchers, data engineers

Repository: https://github.com/allelix/allelix · Python · AGPL-3.0

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